Which of the following is a common sign of gallbladder disease?

Abdominal pain and changes in stool color are common signs of gallbladder disease due to the organ's role in digestion and bile production. When the gallbladder is not functioning properly, often due to conditions like cholecystitis (inflammation of the gallbladder) or gallstones, it can lead to symptoms such as severe abdominal pain, particularly in the upper right quadrant, and alterations in stool color.

Changes in stool color occur because bile salts, which give stool its characteristic brown color, may not be present in sufficient amounts if the gallbladder is obstructed or inflamed. This can result in pale or clay-colored stools. Abdominal pain is a direct result of the inflammation or obstruction caused by the disease, leading to discomfort and other digestive issues.

Understanding these signs can help in identifying gallbladder disease as they directly relate to the functions of the gallbladder and the digestive process. Other options, such as frequent headaches, high blood sugar levels, and skin rashes, do not typically associate with gallbladder conditions and therefore do not reflect the organ's specific pathophysiology.