Which of the following can lead to acute appendicitis?

Acute appendicitis is primarily associated with inflammation of the appendix, which often arises due to an obstruction leading to bacterial overgrowth. Bacterial infection is a significant factor because once the appendix becomes blocked, bacteria can multiply rapidly, causing inflammation and possibly leading to infection of the tissue. This inflammatory process is what characterizes acute appendicitis.

It is important to note that while factors like excessive weight gain, medication use, and excessive fiber intake might influence overall health or digestive function, they do not have a direct causal relationship with the development of appendicitis. Excessive fiber intake can sometimes lead to increased stool bulk and may help prevent constipation, but it does not obstruct the appendix. Therefore, bacterial infection stands out as the primary mechanism that can precipitate an appendicitis episode.